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Article

Identification of novel mutations associated with cycloserine resistance in Mycobacterium tuberculosis.

The Journal of antimicrobial chemotherapy - 1 Dec 2017

Chen Jiazhen, Zhang Shuo, Cui Peng, Shi Wanliang, Zhang Wenhong, Zhang Ying

Abstract excerpt

OBJECTIVES: d-Cycloserine is an important second-line drug used to treat MDR- and XDR-TB. However, the mechanisms of resistance to d-cycloserine are not well understood. Here we investigated the molecular basis of d-cycloserine resistance using in vitro-isolated resistant mutants. METHODS: Mycobacterium tuberculosis H37Rv was subjected to mutant selection on 7H11 agar plates containing varying concentrations of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28961957
DOI: 10.1093/jac/dkx316
PMCID: PMC5890659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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