Article

Integron Gene Cassettes Harboring Novel Variants of D-Alanine-D-Alanine Ligase Confer High-level Resistance to D-Cycloserine

2020-05-09

Abstract excerpt

During a PCR-based screen of antibiotic resistance genes (ARGs) associated with integrons in saliva-derived metagenomic DNA of healthy human volunteers, two novel variants of genes encoding a D-alanine-D-alanine ligase ( ddl6 and ddl7 ) located within gene cassettes in the first position of a reverse integron were identified. Treponema denticola was identified as the likely host of the ddl cassettes. Both ddl...

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Literature Corpus work: 913b586f-9b13-527f-b686-7c7512dddeff
DOI: 10.1101/2020.05.09.085589

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