Mycobacterium smegmatis D-Alanine Racemase Mutants Are Not Dependent on D-Alanine for Growth.

doi:10.1128/AAC.46.2.47-54.2002

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Article

Mycobacterium smegmatis D-Alanine Racemase Mutants Are Not Dependent on D-Alanine for Growth.

Antimicrobial agents and chemotherapy - 1 Jan 2002

Chacon Ofelia, Feng Zhengyu, Harris N Beth, Cáceres Nancy E, Adams L Garry, Barletta Raúl G

Abstract excerpt

Mycobacterium smegmatis is a fast-growing nonpathogenic species particularly useful in studying basic cellular processes of relevance to pathogenic mycobacteria. This study focused on the D-alanine racemase gene (alrA), which is involved in the synthesis of D-alanine, a basic component of peptidoglycan that forms the backbone of the cell wall. M. smegmatis alrA null mutants were generated by homologous...

Topics

Alanine
Alanine Racemase
Antibiotics, Antitubercular
Cycloserine
Microbial Sensitivity Tests
Mutation
Mycobacterium smegmatis
Phenotype

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Identifiers

PMID: 11751110
DOI: 10.1128/AAC.46.2.47-54.2002
PMCID: PMC126997

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