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Article

Assessment of Metabolic Changes in Mycobacterium smegmatis Wild-Type and alr Mutant Strains: Evidence of a New Pathway of d-Alanine Biosynthesis.

Journal of proteome research - 3 Mar 2017

Marshall Darrell D, Halouska Steven, Zinniel Denise K, Fenton Robert J, Kenealy Katie, Chahal Harpreet K, Rathnaiah Govardhan, Barletta Raúl G, Powers Robert

Abstract excerpt

In mycobacteria, d-alanine is an essential precursor for peptidoglycan biosynthesis. The only confirmed enzymatic pathway to form d-alanine is through the racemization of l-alanine by alanine racemase (Alr, EC 5.1.1.1). Nevertheless, the essentiality of Alr in Mycobacterium tuberculosis and Mycobacterium smegmatis for cell survivability in the absence of d-alanine has been a point of controversy with...

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Identifiers

PMID: 28121156
DOI: 10.1021/acs.jproteome.6b00871
PMCID: PMC6599645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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