Article
The effects of signal transducer and activator of transcription three mutations on human platelets.
Platelets - 1 Sept 2018
Aleva Floor E, van de Veerdonk Frank L, Li Yang, Tunjungputri Rahajeng N, Simons Sami, De Groot Philip G, Netea Mihai M, Heijdra Yvonne F, de Mast Quirijn, van der Ven André J A M
Abstract excerpt
Involvement of signal transducer and activator of transcription 3 (STAT3) in inflammation is well known. Recently, a role for STAT3 in platelet activation and platelet production has been suggested. Platelets exhibit important immune functions and engagement of STAT3 in platelet physiology may link inflammation and hemostasis. This study investigated the effects of STAT3 loss-of-function mutations and single...
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