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Article

Reliable diagnosis of IDH-mutant glioblastoma by 2-hydroxyglutarate detection: a study by 3-T magnetic resonance spectroscopy.

Neurosurgical review - 1 Apr 2018

Natsumeda Manabu, Motohashi Kunio, Igarashi Hironaka, Nozawa Takanori, Abe Hideaki, Tsukamoto Yoshihiro, Ogura Ryosuke, Okada Masayasu, Kobayashi Tsutomu, Aoki Hiroshi, Takahashi Hitoshi, Kakita Akiyoshi, Okamoto Kouichirou, Nakada Tsutomu, Fujii Yukihiko

Abstract excerpt

We have previously reported that reliable detection of 2-hydroxyglutarate (2HG) in isocitrate dehydrogenase (IDH)-mutant WHO grade 2 and 3 gliomas is possible utilizing 3.0-T single-voxel magnetic resonance spectroscopy (SVMRS). We set out to determine whether the same method could be applied to detect 2HG in IDH-mutant glioblastoma. Forty-four patients harboring glioblastoma underwent pre-operative MRS...

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Source

Identifiers

PMID: 28956184
DOI: 10.1007/s10143-017-0908-y

Genes

IDH1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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