Article
Construction of a combinatorial pipeline using two somatic variant calling methods for whole exome sequence data of gastric cancer.
The journal of medical investigation : JMI - 1 Jan 2017
Kohmoto Tomohiro, Masuda Kiyoshi, Naruto Takuya, Tange Shoichiro, Shoda Katsutoshi, Hamada Junichi, Saito Masako, Ichikawa Daisuke, Tajima Atsushi, Otsuji Eigo, Imoto Issei
Abstract excerpt
High-throughput next-generation sequencing is a powerful tool to identify the genotypic landscapes of somatic variants and therapeutic targets in various cancers including gastric cancer, forming the basis for personalized medicine in the clinical setting. Although the advent of many computational algorithms leads to higher accuracy in somatic variant calling, no standard method exists due to the limitations of...
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