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Article

Efficient engineering of chromosomal ribosome binding site libraries in mismatch repair proficient Escherichia coli.

Scientific reports - 26 Sept 2017

Oesterle Sabine, Gerngross Daniel, Schmitt Steven, Roberts Tania Michelle, Panke Sven

Abstract excerpt

Multiplexed gene expression optimization via modulation of gene translation efficiency through ribosome binding site (RBS) engineering is a valuable approach for optimizing artificial properties in bacteria, ranging from genetic circuits to production pathways. Established algorithms design smart RBS-libraries based on a single partially-degenerate sequence that efficiently samples the entire space of translation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28951570
DOI: 10.1038/s41598-017-12395-3
PMCID: PMC5615074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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