Article
The HLA-B landscape of Africa: Signatures of pathogen-driven selection and molecular identification of candidate alleles to malaria protection.
Molecular ecology - 1 Nov 2017
Sanchez-Mazas Alicia, Černý Viktor, Di Da, Buhler Stéphane, Podgorná Eliška, Chevallier Elodie, Brunet Lydie, Weber Stephan, Kervaire Barbara, Testi Manuela, Andreani Marco, Tiercy Jean-Marie, Villard Jean, Nunes José Manuel
Abstract excerpt
Human leukocyte antigen (HLA) genes play a key role in the immune response to infectious diseases, some of which are highly prevalent in specific environments, like malaria in sub-Saharan Africa. Former case-control studies showed that one particular HLA-B allele, B*53, was associated with malaria protection in Gambia, but this hypothesis was not tested so far within a population genetics framework. In this...
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