Article
HLA typing of HLA-A, -B, -C, -DPB1, -DQB1 and -DRB1 loci of 226 individuals from three metropolitan areas in South Africa.
Human immunology - 1 Mar 2026
Suzuki Akiko, Baguma Richard, Sawry Shobna, Gill Katherine, Roux Jean Le, Nana Anusha, Patel Faeezah, Garrett Nigel, Sigal Alex, Moore Penny L, Fairlie Lee, Riou Catherine, Burgers Wendy A, Valley-Omar Ziyaad
Abstract excerpt
The aim of this study was to characterize HLA diversity in individuals from clinical research sites in order to better understand T cell responses to COVID-19 vaccines in relation to their HLA profiles. Next-generation sequence-based typing of the HLA-A, -B, -C, -DPB1, -DQB1 and -DRB1 loci is reported for 226 individuals from three metropolitan areas in South Africa. Overall, the frequencies of both class I and...
Topics
- Humans
- South Africa
- Gene Frequency
- HLA-DP beta-Chains
- Histocompatibility Testing
- HLA-DRB1 Chains
- HLA-B Antigens
- HLA-C Antigens
- HLA-A Antigens
- HLA-DQ beta-Chains
- Alleles
- Haplotypes
- Genotype