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Article

Extensive genetic diversity in the HLA class II region of Africans, with a focally predominant allele, DRB1*1304.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1992

Hill A V, Allsopp C E, Kwiatkowski D, Taylor T E, Yates S N, Anstey N M, Wirima J J, Brewster D R, McMichael A J, Molyneux M E

Abstract excerpt

Molecular HLA class II typing of greater than 1700 individuals from The Gambia in West Africa and Malawi in South-Central Africa revealed a striking diversity of HLA DRB-DQB haplotypes as defined by restriction fragment length polymorphism (RFLP); this diversity is twice as extensive as that found in northern Europeans. Despite this diversity, sequence and PCR/oligonucleotide analysis showed that the recently...

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Identifiers

PMID: 1347946
DOI: 10.1073/pnas.89.6.2277
PMCID: PMC48640

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