Article
Extensive genetic diversity in the HLA class II region of Africans, with a focally predominant allele, DRB1*1304.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1992
Hill A V, Allsopp C E, Kwiatkowski D, Taylor T E, Yates S N, Anstey N M, Wirima J J, Brewster D R, McMichael A J, Molyneux M E
Abstract excerpt
Molecular HLA class II typing of greater than 1700 individuals from The Gambia in West Africa and Malawi in South-Central Africa revealed a striking diversity of HLA DRB-DQB haplotypes as defined by restriction fragment length polymorphism (RFLP); this diversity is twice as extensive as that found in northern Europeans. Despite this diversity, sequence and PCR/oligonucleotide analysis showed that the recently...
Topics
- Alleles
- Black People
- DNA
- Gambia
- Gene Frequency
- Genes, MHC Class II
- Genetic Variation
- HLA-DR Antigens
- HLA-DRB1 Chains
- Haplotypes
- Histocompatibility Antigens Class II