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Article

Sliding clamp-DNA interactions are required for viability and contribute to DNA polymerase management in Escherichia coli.

Journal of molecular biology - 20 Mar 2009

Heltzel Justin M H, Scouten Ponticelli Sarah K, Sanders Laurie H, Duzen Jill M, Cody Vivian, Pace James, Snell Edward H, Sutton Mark D

Abstract excerpt

Sliding clamp proteins topologically encircle DNA and play vital roles in coordinating the actions of various DNA replication, repair, and damage tolerance proteins. At least three distinct surfaces of the Escherichia coli beta clamp interact physically with the DNA that it topologically encircles. We utilized mutant beta clamp proteins bearing G66E and G174A substitutions (beta159), affecting the single-stranded...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19361435
DOI: 10.1016/j.jmb.2009.01.050
PMCID: PMC2670953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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