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Article

Replication fork inhibition in seqA mutants of Escherichia coli triggers replication fork breakage.

Molecular microbiology - 1 Jul 2014

Rotman Ella, Khan Sharik R, Kouzminova Elena, Kuzminov Andrei

Abstract excerpt

SeqA protein negatively regulates replication initiation in Escherichia coli and is also proposed to organize maturation and segregation of the newly replicated DNA. The seqA mutants suffer from chromosomal fragmentation; since this fragmentation is attributed to defective segregation or nucleoid compaction, two-ended breaks are expected. Instead, we show that, in SeqA's absence, chromosomes mostly suffer...

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Identifiers

PMID: 24806348
DOI: 10.1111/mmi.12638
PMCID: PMC4078979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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