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Article

Vitamin C-Induced Epigenetic Modifications in Donor NSCs Establish Midbrain Marker Expressions Critical for Cell-Based Therapy in Parkinson's Disease.

Stem cell reports - 10 Oct 2017

Wulansari Noviana, Kim Eun-Hee, Sulistio Yanuar Alan, Rhee Yong-Hee, Song Jae-Jin, Lee Sang-Hun

Abstract excerpt

Cultured neural stem/precursor cells (NSCs) are regarded as a potential systematic cell source to treat Parkinson's disease (PD). However, the therapeutic potential of these cultured NSCs is lost during culturing. Here, we show that treatment of vitamin C (VC) enhances generation of authentic midbrain-type dopamine (mDA) neurons with improved survival and functions from ventral midbrain (VM)-derived NSCs. VC...

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Identifiers

PMID: 28943252
DOI: 10.1016/j.stemcr.2017.08.017
PMCID: PMC5639382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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