Dopaminergic-like neurons derived from oral mucosa stem cells by developmental cues improve symptoms in the hemi-parkinsonian rat model.

doi:10.1371/journal.pone.0100445

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Dopaminergic-like neurons derived from oral mucosa stem cells by developmental cues improve symptoms in the hemi-parkinsonian rat model.

PloS one - 1 Jan 2014

Ganz Javier, Arie Ina, Buch Sigal, Zur Tali Ben, Barhum Yael, Pour Sammy, Araidy Shareef, Pitaru Sandu, Offen Daniel

Abstract excerpt

Achieving safe and readily accessible sources for cell replacement therapy in Parkinson's disease (PD) is still a challenging unresolved issue. Recently, a primitive neural crest stem cell population (hOMSC) was isolated from the adult human oral mucosa and characterized in vitro and in vivo. In this study we assessed hOMSC ability to differentiate into dopamine-secreting cells with a neuronal-dopaminergic...

Topics

Adult
Animals
Biomarkers
Cell Differentiation
Cell Nucleus
Cues
Disease Models, Animal
Dopamine
Dopaminergic Neurons
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mouth Mucosa

Neostriatum

Parkinson Disease

Phenotype

Rats, Sprague-Dawley

Stem Cell Transplantation

Source

Open in PubMed Open full text

Identifiers

PMID: 24945922
DOI: 10.1371/journal.pone.0100445
PMCID: PMC4063966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dopaminergic-like neurons derived from oral mucosa stem cells by developmental cues improve symptoms in the hemi-parkinsonian rat model.PMID 24945922Read ↗

Human embryonic stem cells-derived dopaminergic neurons transplanted in parkinsonian monkeys recover dopamine levels and motor behaviorSemantic proximity Read ↗

Directed Dopaminergic Neuron Differentiation from Human Pluripotent Stem CellsSemantic proximity Read ↗

Enhanced yield and subtype identity of hPSC-derived midbrain dopamine neuron by modulation of WNT and FGF18 signalingSemantic proximity Read ↗

Specification of a dopaminergic phenotype from adult human mesenchymal stem cells.Semantic proximity Read ↗

Multi-omics reveal critical differentiation target for Parkinson’s Disease-vulnerable midbrain dopaminergic neuronsSemantic proximity Read ↗

Dopaminergic neurons from midbrain-specified human embryonic stem cell-derived neural stem cells engrafted in a monkey model of Parkinson's disease.Semantic proximity Read ↗

Parkinson's Disease and Mesenchymal Stem Cells: Potential for Cell-Based TherapySemantic proximity Read ↗

Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease.Semantic proximity Read ↗

Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells.Semantic proximity Read ↗

Engineering functional ventral midbrain dopaminergic neurons in human organoids through WNT modulation and bioreactor cultureSemantic proximity Read ↗

Brain Organoids in Parkinson’s Disease Drug Development: Human-Specific Models for Translational DiscoverySemantic proximity Read ↗

Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.