Article
Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease.
Neurobiology of aging - 1 Dec 2017
Horgusluoglu-Moloch Emrin, Nho Kwangsik, Risacher Shannon L, Kim Sungeun, Foroud Tatiana, Shaw Leslie M, Trojanowski John Q, Aisen Paul S, Petersen Ronald C, Jack Clifford R, Lovestone Simon, Simmons Andrew, Weiner Michael W, Saykin Andrew J
Abstract excerpt
Alzheimer's disease (AD) patients display hippocampal atrophy, memory impairment, and cognitive decline. New neurons are generated throughout adulthood in 2 regions of the brain implicated in AD, the dentate gyrus of the hippocampus and the subventricular zone of the olfactory bulb. Disruption of this process contributes to neurodegenerative diseases including AD, and many of the molecular players in AD are also...
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