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Article

Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease.

NeuroImage - 1 Jun 2010

Stein Jason L, Hua Xue, Morra Jonathan H, Lee Suh, Hibar Derrek P, Ho April J, Leow Alex D, Toga Arthur W, Sul Jae Hoon, Kang Hyun Min, Eskin Eleazar, Saykin Andrew J, Shen Li, Foroud Tatiana, Pankratz Nathan, Huentelman Matthew J, Craig David W, Gerber Jill D, Allen April N, Corneveaux Jason J, Stephan Dietrich A, Webster Jennifer, DeChairo Bryan M, Potkin Steven G, Jack Clifford R, Weiner Michael W, Thompson Paul M

Abstract excerpt

In a genome-wide association study of structural brain degeneration, we mapped the 3D profile of temporal lobe volume differences in 742 brain MRI scans of Alzheimer's disease patients, mildly impaired, and healthy elderly subjects. After searching 546,314 genomic markers, 2 single nucleotide polymorphisms (SNPs) were associated with bilateral temporal lobe volume (P<5 x 10(-7)). One SNP, rs10845840, is located...

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Source

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Identifiers

PMID: 20197096
DOI: 10.1016/j.neuroimage.2010.02.068
PMCID: PMC2856746

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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