Article
FASTKD2 is associated with memory and hippocampal structure in older adults.
Molecular psychiatry - 1 Oct 2015
Ramanan V K, Nho K, Shen L, Risacher S L, Kim S, McDonald B C, Farlow M R, Foroud T M, Gao S, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Aisen P S, Petersen R C, Jack C R, Shaw L M, Trojanowski J Q, Weiner M W, Green R C, Toga A W, De Jager P L, Yu L, Bennett D A, Saykin A J
Abstract excerpt
Memory impairment is the cardinal early feature of Alzheimer's disease, a highly prevalent disorder whose causes remain only partially understood. To identify novel genetic predictors, we used an integrative genomics approach to perform the largest study to date of human memory (n=14 781). Using a genome-wide screen, we discovered a novel association of a polymorphism in the pro-apoptotic gene FASTKD2...
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