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Article

Inflammaging: disturbed interplay between autophagy and inflammasomes.

Aging - 1 Mar 2012

Salminen Antero, Kaarniranta Kai, Kauppinen Anu

Abstract excerpt

Inflammaging refers to a low-grade pro-inflammatory phenotype which accompanies aging in mammals. The aging process is associated with a decline in autophagic capacity which impairs cellular housekeeping, leading to protein aggregation and accumulation of dysfunctional mitochondria which provoke reactive oxygen species (ROS) production and oxidative stress. Recent studies have clearly indicated that the ROS...

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Source

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Identifiers

PMID: 22411934
DOI: 10.18632/aging.100444
PMCID: PMC3348477

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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