Article
Amyotrophic lateral sclerosis: from current developments in the laboratory to clinical implications.
Antioxidants & redox signaling - 1 Mar 2008
Cozzolino Mauro, Ferri Alberto, Carrì Maria Teresa
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a late-onset progressive degeneration of motor neurons occurring both as a sporadic and a familial disease. The etiology of ALS remains unknown, but one fifth of instances are due to specific gene defects, the best characterized of which is point mutations in the gene coding for Cu/Zn superoxide dismutase (SOD1). Because sporadic and familial ALS affect the same neurons with...
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