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Article

Inflammasome mediated neuronal-microglial crosstalk: a therapeutic substrate of the familial C9orf72 variant of frontotemporal dementia/amyotrophic lateral sclerosis

2023-01-16

Abstract excerpt

<title>Abstract</title> <p>Intronic G<sub>4</sub>C<sub>2</sub> hexanucleotide repeat expansions (HRE) of <italic>C9orf72</italic> are the most common cause of familial variants of frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS). G<sub>4</sub>C<sub>2</sub> HREs in <italic>C9orf72</italic> undergo non-canonical repeat-associated translation, producing dipeptide repeat (DPR) proteins, with various de...

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Literature Corpus work
6496d69a-0d77-5d45-9b63-5b4270fecb00
DOI
10.21203/rs.3.rs-2420211/v1
Open publication

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Inflammasome mediated neuronal-microglial crosstalk: a therapeutic substrate of the familial C9orf72 variant of frontotemporal dementia/amyotrophic lateral sclerosisDOI 10.21203/rs.3.rs-2420211/v1
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