STN1–POLA2 interaction provides a basis for primase-pol α stimulation by human STN1

Abstract excerpt

The CST (CTC1-STN1-TEN1) complex mediates critical functions in maintaining telomere DNA and overcoming genome-wide replication stress. A conserved biochemical function of the CST complex is its primase-Pol α (PP) stimulatory activity. In this report, we demonstrate the ability of purified human STN1 alone to promote PP activity in vitro. We show that this regulation is mediated primarily by the N-terminal OB...

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• Share to Advanced biosensing and bioanalysis techniques
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