Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural Basis for Clonal Diversity of the Public T Cell Response to a Dominant Human Cytomegalovirus Epitope

2 Oct 2015

Abstract excerpt

Cytomegalovirus (CMV) is a ubiquitous and persistent human pathogen that is kept in check by CD8(+) cytotoxic T lymphocytes. Individuals expressing the major histocompatibility complex (MHC) class I molecule HLA-A2 produce cytotoxic T lymphocytes bearing T cell receptors (TCRs) that recognize the immunodominant CMV epitope NLVPMVATV (NLV). The NLV-specific T cell repertoire is characterized by a high prevalence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26429912
DOI: 10.1074/jbc.m115.691311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural Basis for Clonal Diversity of the Public T Cell Response to a Dominant Human Cytomegalovirus EpitopePMID 26429912Read ↗

Selection of T Cell Clones Expressing High-Affinity Public TCRs within Human Cytomegalovirus-Specific CD8 T Cell ResponsesSemantic proximity Read ↗

Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8+ TCR Repertoires to Immunodominant Viral AntigensSemantic proximity Read ↗

Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection.Semantic proximity Read ↗

Antigen-Specific TCR Signatures of Cytomegalovirus InfectionSemantic proximity Read ↗

Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope.Semantic proximity Read ↗

T Cell Receptor αβ Diversity Inversely Correlates with Pathogen-Specific Antibody Levels in Human Cytomegalovirus InfectionSemantic proximity Read ↗

TCR repertoire evolution during maintenance of CMV-specific T-cell populations.Semantic proximity Read ↗

Long-term stable expanded human CD4+ T cell clones specific for human cytomegalovirus are distributed in both CD45RAhigh and CD45ROhigh populations.Semantic proximity Read ↗

Molecular imprint of exposure to naturally occurring genetic variants of human cytomegalovirus on the T cell repertoire.Semantic proximity Read ↗

Public and private human T cell clones respond differentially to HCMV antigen when boosted by CD3 co-potentiationSemantic proximity Read ↗

Public T-Cell Receptors (TCRs) Revisited by Analysis of the Magnitude of Identical and Highly-Similar TCRs in Virus-Specific T-Cell Repertoires of Healthy IndividualsSemantic proximity Read ↗

Broadly targeted human cytomegalovirus-specific CD4 <b>+</b> and CD8 <b>+</b> T cells dominate the memory compartments of exposed subjectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.