Article
Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling.
European cells & materials - 20 Sept 2017
Thompson C L, Plant J C, Wann A K, Bishop C L, Novak P, Mitchison H M, Beales P L, Chapple J P, Knight M M
Abstract excerpt
Tissue engineering-based therapies targeting cartilage diseases, such as osteoarthritis, require in vitro expansion of articular chondrocytes. A major obstacle for these therapies is the dedifferentiation and loss of phenotype accompanying chondrocyte expansion. Recent studies suggest that manipulation of hedgehog signalling may be used to promote chondrocyte re-differentiation. Hedgehog signalling requires the...
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