Article

Matrix stiffness controls ciliogenesis and centriole position

2021-08-12

Abstract excerpt

Mechanical stress and the stiffness of the extracellular matrix are key drivers of tissue development and homeostasis. Aberrant mechanosensation is associated with a wide range of pathologies, including diseases such as osteoarthritis. Substrate stiffness is one of the well-known mechanical properties of the matrix that enabled establishing the central dogma of an integrin-mediated mechanotransduction using stem c...

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Literature Corpus work: a49a2e5f-93ec-53c0-bede-04ff5772e3dc
DOI: 10.1101/2021.08.12.452439

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