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Article

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium

1 Dec 2013

Abstract excerpt

BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β). We have also shown the primary cilium elongates in response to IL-1β exposure. Both anabolic phenotype and inflammatory pathology are proposed to be dependent on...

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PMID: 24330727
DOI: 10.1186/2046-2530-2-17

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