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Article

Persistent aberrant cortical phase-amplitude coupling following seizure treatment in absence epilepsy models.

The Journal of physiology - 1 Dec 2017

Maheshwari Atul, Akbar Abraham, Wang Mai, Marks Rachel L, Yu Katherine, Park Suhyeorn, Foster Brett L, Noebels Jeffrey L

Abstract excerpt

KEY POINTS: In two monogenic models of absence epilepsy, interictal beta/gamma power is augmented in homozygous stargazer (stg/stg) but not homozygous tottering (tg/tg) mice. There are distinct gene-linked patterns of aberrant phase-amplitude coupling in the interictal EEG of both stg/stg and tg/tg mice, compared to +/+ and stg/+ mice. Treatment with ethosuximide significantly blocks seizures in both genotypes,...

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Identifiers

PMID: 28901011
DOI: 10.1113/JP274696
PMCID: PMC5709336

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Source receipt: pubmed, retrieved 7 Sept 2026.

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