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Low-dose Perampanel rescues cortical gamma dysregulation associated with parvalbumin interneuron GluA2 upregulation in epileptic <i>Syngap1</i> <sup>+/-</sup> mice

2019-07-30

Abstract excerpt

Loss-of-function SYNGAP1 mutations cause a neurodevelopmental disorder characterized by intellectual disability and epilepsy. SYNGAP1 is a Ras-GTPase-activating protein that underlies the formation and experience-dependent regulation of postsynaptic densities. The mechanisms that contribute to this proposed monogenic cause of intellectual disability and epilepsy remain unresolved. Here, we establish the phenotype...

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Literature Corpus work
feeb230e-ca32-52a1-997f-545250c7df09
DOI
10.1101/718965
Open publication

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Low-dose Perampanel rescues cortical gamma dysregulation associated with parvalbumin interneuron GluA2 upregulation in epileptic <i>Syngap1</i> <sup>+/-</sup> miceDOI 10.1101/718965
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