Article
Shift in interictal relative gamma power as a novel biomarker for drug response in two mouse models of absence epilepsy.
Epilepsia - 1 Jan 2016
Maheshwari Atul, Marks Rachel L, Yu Katherine M, Noebels Jeffrey L
Abstract excerpt
OBJECTIVE: Two monogenic mouse models of childhood absence epilepsy, stargazer and tottering, differ strikingly in their response to N-methyl-d-aspartate (NMDA) receptor blockade. We sought to evaluate the change in interictal relative gamma power as a reliable biomarker for this gene-linked antiepileptic drug (AED) response. METHODS: The effects of AEDs on absolute and relative (to the total) power of...
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