Single locus mutations in mice expressing generalized spike-wave absence epilepsies.

Abstract excerpt

Studies in mutant mice are beginning to reveal important general principles regarding the heredity of the spike-wave cortical synchronization trait. First, a defect at a single gene locus is sufficient to produce a generalized spike-wave seizure disorder. Second, the EEG pattern itself is genetically heterogeneous, and can arise from mutations in at least five independent loci. Third, the intervening cellular...

Topics

• Action Potentials
• Animals
• Chromosome Mapping
• Cortical Synchronization
• Electroencephalography
• Epilepsy, Absence
• Mice
• Mice, Neurologic Mutants
• Phenotype
• Syndrome