Article

Convergent Inhibitory Cortical Circuit Disruption Drives Genetically Distinct Absence Seizures

2026-07-16

Abstract excerpt

Absence seizures, the most common childhood epilepsy, are characterized by brief involuntary lapses in consciousness and 3-Hz spike-wave EEG discharges (SWD). Despite extensive documentation of pathogenic thalamic remodeling, the cortical circuit abnormalities driving this highly stereotyped SWD remain elusive. Using two of the best characterized mouse models of absence epilepsy carrying point mutations in distinc...

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Literature Corpus work: 1887007f-a583-5e65-a14a-4999aaf28b69
DOI: 10.64898/2026.07.10.737818

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