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Article

Interrogation of γ-tubulin alleles using high-resolution fitness measurements reveals a distinct cytoplasmic function in spindle alignment.

Scientific reports - 12 Sept 2017

Shulist Kristian, Yen Eric, Kaitna Susanne, Leary Allen, Decterov Alexandra, Gupta Debarun, Vogel Jackie

Abstract excerpt

γ-Tubulin has a well-established role in nucleating the assembly of microtubules, yet how phosphorylation regulates its activity remains unclear. Here, we use a time-resolved, fitness-based SGA approach to compare two γ-tubulin alleles, and find that the genetic interaction profile of γtub-Y362E is enriched in spindle positioning and cell polarity genes relative to that of γtub-Y445D, which is enriched in genes...

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Identifiers

PMID: 28900268
DOI: 10.1038/s41598-017-11789-7
PMCID: PMC5595808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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