Article
Phosphorylation of gamma-tubulin regulates microtubule organization in budding yeast.
Developmental cell - 1 Nov 2001
Vogel J, Drapkin B, Oomen J, Beach D, Bloom K, Snyder M
Abstract excerpt
gamma-Tubulin is essential for microtubule nucleation in yeast and other organisms; whether this protein is regulated in vivo has not been explored. We show that the budding yeast gamma-tubulin (Tub4p) is phosphorylated in vivo. Hyperphosphorylated Tub4p isoforms are restricted to G1. A conserved tyrosine near the carboxy terminus (Tyr445) is required for phosphorylation in vivo. A point mutation, Tyr445 to Asp,...
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