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Article

Identification of the distinct genomic features in gastroesophageal junction adenocarcinoma and its Siewert subtypes.

The Journal of pathology - 1 Nov 2020

Geng Qirong, Lao Jiawen, Zuo Xiaoyu, Chen Shangxiang, Bei Jin-Xin, Xu Dazhi

Abstract excerpt

Rates of gastroesophageal junction adenocarcinomas (GEJAs) have shown an alarming increase; however, the genetic background of GEJA and its Siewert classification have yet to be uncovered. Here, 60 paired tumor and normal DNA samples from GEJA patients were analyzed by whole-exome sequencing. Among them, 13 were Siewert type I, 14 were type II, and 33 were type III. A predominance of C/G>T/A substitutions was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32715475
DOI: 10.1002/path.5516

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