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Article

Abnormal expression of FLI1 protein is an adverse prognostic factor in acute myeloid leukemia

15 Sept 2011

Abstract excerpt

Friend leukemia virus integration 1 (FLI1), an Ets transcription factor family member, is linked to acute myelogenous leukemia (AML) by chromosomal events at the FLI1 locus, but the biologic impact of FLI1 expression on AML is unknown. FLI1 protein expression was measured in 511 newly diagnosed AML patients. Expression was similar in peripheral blood (PB) and BM and higher at diagnosis than at relapse (P = .02)....

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PMID: 21917756
DOI: 10.1182/blood-2011-04-348052

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