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Article

Zfp423/ZNF423 regulates cell cycle progression, the mode of cell division and the DNA-damage response in Purkinje neuron progenitors.

Development (Cambridge, England) - 15 Oct 2017

Casoni Filippo, Croci Laura, Bosone Camilla, D'Ambrosio Roberta, Badaloni Aurora, Gaudesi Davide, Barili Valeria, Sarna Justyna R, Tessarollo Lino, Cremona Ottavio, Hawkes Richard, Warming Søren, Consalez G Giacomo

Abstract excerpt

The Zfp423/ZNF423 gene encodes a 30-zinc-finger transcription factor involved in key developmental pathways. Although null Zfp423 mutants develop cerebellar malformations, the underlying mechanism remains unknown. ZNF423 mutations are associated with Joubert Syndrome, a ciliopathy causing cerebellar vermis hypoplasia and ataxia. ZNF423 participates in the DNA-damage response (DDR), raising questions regarding its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28893945
DOI: 10.1242/dev.155077
PMCID: PMC5675449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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