Article
Zfp423 is required for normal cerebellar development.
Molecular and cellular biology - 1 Sept 2006
Warming Søren, Rachel Rivka A, Jenkins Nancy A, Copeland Neal G
Abstract excerpt
Zinc finger protein 423 (also known as Ebf-associated zinc finger protein, Ebfaz) binds to and negatively regulates Ebf1, a basic helix-loop-helix transcription factor required for B-cell lineage commitment and olfactory epithelium development. Zfp423 also binds to Smad1/Smad4 in response to Bmp2 signaling. Zfp423 contains 30 Krüppel-like zinc fingers that are organized into discrete clusters; some zinc fingers...
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