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ZNF423: Transcriptional modulation in development and cancer

15 Sept 2014

Abstract excerpt

Krüppel-like zinc finger proteins are versatile players in biology that have been implicated in mammalian development and disease. Among these proteins, ZNF423 and its mouse ortholog Zfp423 were initially implicated in midline patterning of the central nervous system but have emerged as critical transcriptional modulators in cancer. Epigenetically uncurbed ZNF423 interferes with lymphopoiesis by sequestration of...

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PMID: 27308357
DOI: 10.4161/23723548.2014.969655

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