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Article

Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly.

Scientific reports - 8 Mar 2017

Sgourdou Paraskevi, Mishra-Gorur Ketu, Saotome Ichiko, Henagariu Octavian, Tuysuz Beyhan, Campos Cynthia, Ishigame Keiko, Giannikou Krinio, Quon Jennifer L, Sestan Nenad, Caglayan Ahmet O, Gunel Murat, Louvi Angeliki

Abstract excerpt

Recessive mutations in WD repeat domain 62 (WDR62) cause microcephaly and a wide spectrum of severe brain malformations. Disruption of the mouse ortholog results in microcephaly underlain by reduced proliferation of neocortical progenitors during late neurogenesis, abnormalities in asymmetric centrosome inheritance leading to neuronal migration delays, and altered neuronal differentiation. Spindle pole...

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Identifiers

PMID: 28272472
DOI: 10.1038/srep43708
PMCID: PMC5341122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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