Integrated molecular analysis of clear-cell renal cell carcinoma.

doi:10.1038/ng.2699

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Article

Integrated molecular analysis of clear-cell renal cell carcinoma.

Nature genetics - 1 Aug 2013

Sato Yusuke, Yoshizato Tetsuichi, Shiraishi Yuichi, Maekawa Shigekatsu, Okuno Yusuke, Kamura Takumi, Shimamura Teppei, Sato-Otsubo Aiko, Nagae Genta, Suzuki Hiromichi, Nagata Yasunobu, Yoshida Kenichi, Kon Ayana, Suzuki Yutaka, Chiba Kenichi, Tanaka Hiroko, Niida Atsushi, Fujimoto Akihiro, Tsunoda Tatsuhiko, Morikawa Teppei, Maeda Daichi, Kume Haruki, Sugano Sumio, Fukayama Masashi, Aburatani Hiroyuki, Sanada Masashi, Miyano Satoru, Homma Yukio, Ogawa Seishi

Abstract excerpt

Clear-cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer and its molecular pathogenesis is incompletely understood. Here we report an integrated molecular study of ccRCC in which ≥100 ccRCC cases were fully analyzed by whole-genome and/or whole-exome and RNA sequencing as well as by array-based gene expression, copy number and/or methylation analyses. We identified a full spectrum of genetic...

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Identifiers

PMID: 23797736
DOI: 10.1038/ng.2699

Genes

VHL
CUL3
KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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