Article
VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.
Science (New York, N.Y.) - 20 Jul 2018
Zhang Jing, Wu Tao, Simon Jeremy, Takada Mamoru, Saito Ryoichi, Fan Cheng, Liu Xian-De, Jonasch Eric, Xie Ling, Chen Xian, Yao Xiaosai, Teh Bin Tean, Tan Patrick, Zheng Xingnan, Li Mingjie, Lawrence Cortney, Fan Jie, Geng Jiang, Liu Xijuan, Hu Lianxin, Wang Jun, Liao Chengheng, Hong Kai, Zurlo Giada, Parker Joel S, Auman J Todd, Perou Charles M, Rathmell W Kimryn, Kim William Y, Kirschner Marc W, Kaelin William G, Baldwin Albert S, Zhang Qing
Abstract excerpt
Inactivation of the von Hippel-Lindau (VHL) E3 ubiquitin ligase protein is a hallmark of clear cell renal cell carcinoma (ccRCC). Identifying how pathways affected by VHL loss contribute to ccRCC remains challenging. We used a genome-wide in vitro expression strategy to identify proteins that bind VHL when hydroxylated. Zinc fingers and homeoboxes 2 (ZHX2) was found as a VHL target, and its hydroxylation allowed...
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