Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNF4 controls the extent of replication fork reversal to preserve genome stability

30 May 2022

Abstract excerpt

Replication fork reversal occurs via a two-step process that entails reversal initiation and reversal extension. DNA topoisomerase IIalpha (TOP2A) facilitates extensive fork reversal, on one hand through resolving the topological stress generated by the initial reversal, on the other hand via its role in recruiting the SUMO-targeted DNA translocase PICH to stalled forks in a manner that is dependent on its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to DNA Repair Mechanisms
Share to Polyomavirus and related diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35640614
DOI: 10.1093/nar/gkac447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNF4 controls the extent of replication fork reversal to preserve genome stabilityPMID 35640614Read ↗

Replication Fork Reversal and ProtectionSemantic proximity Read ↗

Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity.Semantic proximity Read ↗

Advances in understanding DNA processing and protection at stalled replication forksSemantic proximity Read ↗

Disparate requirements for RAD54L in replication fork reversalSemantic proximity Read ↗

Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis.Semantic proximity Read ↗

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cellsSemantic proximity Read ↗

Coordinated protein and DNA remodeling by human HLTF on stalled replication forkSemantic proximity Read ↗

TRF1 relies on fork reversal to prevent fragility at human telomeresSemantic proximity Read ↗

SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage.Semantic proximity Read ↗

HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal.Semantic proximity Read ↗

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.Semantic proximity Read ↗

Topological regulation of the estrogen transcriptional response by ZATT-mediated inhibition of TOP2B activitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.