Article
PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features.
Cancer science - 1 May 2022
Fukui Katsuya, Nomura Miyuki, Kishimoto Kazuhiro, Tanuma Nobuhiro, Kurosawa Koreyuki, Kanazawa Kosuke, Kato Hiroyuki, Sato Tomoki, Miura Shinji, Miura Koh, Sato Ikuro, Tsuji Hiroyuki, Yamashita Yoji, Tamai Keiichi, Watanabe Toshio, Yasuda Jun, Tanaka Takuji, Satoh Kennichi, Furukawa Toru, Jingu Keiichi, Shima Hiroshi
Abstract excerpt
To examine effects of PP6 gene (Ppp6c) deficiency on pancreatic tumor development, we developed pancreas-specific, tamoxifen-inducible Cre-mediated KP (KRAS(G12D) plus Trp53-deficient) mice (cKP mice) and crossed them with Ppp6cflox / flox mice. cKP mice with the homozygous Ppp6c deletion developed pancreatic tumors, became emaciated and required euthanasia within 150 days of mutation induction, phenotypes that...
Topics
- Animals
- Cachexia
- Carcinogenesis
- Carcinoma, Pancreatic Ductal
- Humans
- Mice
- Mutation
- Pancreatic Neoplasms
- Phosphoprotein Phosphatases