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Article

E-cadherin expression in obesity-associated, Kras-initiated pancreatic ductal adenocarcinoma in mice.

Surgery - 1 Dec 2015

Stark Alexander P, Chang Hui-Hua, Jung Xiaoman, Moro Aune, Hertzer Kathleen, Xu Mu, Schmidt Andrea, Hines O Joe, Eibl Guido

Abstract excerpt

BACKGROUND: The epithelial-mesenchymal transition (EMT) is critical in the development of invasive epithelial malignancies. EMT is accelerated by inflammation and results in decreased E-cadherin expression. Diet-induced obesity is an inflammatory state that accelerates pancreatic carcinogenesis; its effect on EMT and E-cadherin expression in the development of pancreatic ductal adenocarcinoma is unclear. METHODS:...

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Identifiers

PMID: 26297056
DOI: 10.1016/j.surg.2015.07.023
PMCID: PMC4637247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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