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Article

SOCS2 Binds to and Regulates EphA2 through Multiple Mechanisms.

Scientific reports - 7 Sept 2017

Pilling Carissa, Cooper Jonathan A

Abstract excerpt

Suppressors of cytokine signaling (SOCS) proteins inhibit signaling by serving as substrate receptors for the Cullin5-RING E3 ubiquitin ligase (CRL5) and through a variety of CRL5-independent mechanisms. CRL5, SOCS2 and SOCS6 are implicated in suppressing transformation of epithelial cells. We identified cell proteins that interact with SOCS2 and SOCS6 using two parallel proteomics techniques: BioID and Flag...

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Source

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Identifiers

PMID: 28883622
DOI: 10.1038/s41598-017-11040-3
PMCID: PMC5589800

Genes

SOCS2
SOCS6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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