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Article

FSTL1 Promotes Metastasis and Chemoresistance in Esophageal Squamous Cell Carcinoma through NFκB–BMP Signaling Cross-talk

7 Sept 2017

Abstract excerpt

Abstract Esophageal squamous cell carcinoma (ESCC) has a generally poor prognosis, and molecular markers to improve early detection and predict outcomes are greatly needed. Here, we report that the BMP-binding follistatin-like protein FSTL1 is overexpressed in ESCCs, where it correlates with poor overall survival. Genetic amplification of FSTL1 or chromosome 3q, where it is located, occurred frequently in ESCC,...

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PMID: 28883005
DOI: 10.1158/0008-5472.can-17-1411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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