Article
FAT1 prevents epithelial mesenchymal transition (EMT) via MAPK/ERK signaling pathway in esophageal squamous cell cancer.
Cancer letters - 1 Jul 2017
Hu Xiaoling, Zhai Yuanfang, Kong Pengzhou, Cui Heyang, Yan Ting, Yang Jian, Qian Yu, Ma Yanchun, Wang Fang, Li Hongyi, Cheng Caixia, Zhang Ling, Jia Zhiwu, Li Yaoping, Yang Bin, Xu Enwei, Wang Juan, Yang Jie, Bi Yanghui, Chang Lu, Wang Yi, Zhang Yingchun, Song Bin, Li Guodong, Shi Ruyi, Liu Jing, Zhang Mingsheng, Cheng Xiaolong, Cui Yongping
Abstract excerpt
FAT1 regulates cell-cell adhesion, cell growth, cell migration, and actin dynamics as either oncogene or tumor suppressor in human cancers. We previously identified FAT1 was one of significant mutant genes in esophageal squamous cell carcinoma (ESCC). However, the function and underlying mechanism of FAT1 in ESCC have not been explored. In this study, we report that FAT1 expression was significantly lower in ESCC...
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