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Article

FSTL4 interaction with Gαi proteins activates the Akt-mTOR pathway to drive malignant phenotypes in non-small cell lung cancer.

Cell communication and signaling : CCS - 17 Jun 2026

Li Jiaxin, Qi Wanghong, Gao Shansong, Zhu Yifei, Zha Jianhua

Abstract excerpt

Non-small cell lung cancer (NSCLC) presents a critical challenge clinically; thus, identifying novel drivers and reliable prognostic biomarkers is imperative. Here, we investigated the clinical relevance, cell-type-specific localization, and mechanistic role of Follistatin-like 4 (FSTL4) in NSCLC. Analysis of The Cancer Genome Atlas (TCGA) and local resected tissue samples show that FSTL4 expression is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Share to Proto-Oncogene Proteins c-akt

Share to TOR Serine-Threonine Kinases

Source

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Identifiers

PMID: 42310642
DOI: 10.1186/s12964-026-03001-z
PMCID: PMC13508297

Genes

FSTL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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