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Article

High-Level Resistance to Colistin Mediated by Various Mutations in the crrB Gene among Carbapenemase-Producing Klebsiella pneumoniae.

Antimicrobial agents and chemotherapy - 1 Nov 2017

Jayol Aurélie, Nordmann Patrice, Brink Adrian, Villegas Maria-Virginia, Dubois Véronique, Poirel Laurent

Abstract excerpt

Mutations in crrAB genes encoding a two-component regulator involved in modifications of lipopolysaccharide were searched for among a collection of colistin-resistant Klebsiella pneumoniae isolates. Four isolates, respectively, producing carbapenemases NDM-1, OXA-181, or KPC-2 showed mutated CrrB proteins compared with those in wild-type strains. Complementation assays with a wild-type CrrB protein restored the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28874377
DOI: 10.1128/AAC.01423-17
PMCID: PMC5655078

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