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Colistin Heteroresistance and Involvement of the PmrAB Regulatory System in Acinetobacter baumannii.

Antimicrobial agents and chemotherapy - 1 Sept 2018

Charretier Yannick, Diene Seydina M, Baud Damien, Chatellier Sonia, Santiago-Allexant Emmanuelle, van Belkum Alex, Guigon Ghislaine, Schrenzel Jacques

Abstract excerpt

Multidrug-resistant Acinetobacter baumannii infection has recently emerged as a worldwide clinical problem, and colistin is increasingly being used as a last-resort therapy. Despite its favorable bacterial killing, resistance and heteroresistance (HR) to colistin have been described. The purpose of the present study was to investigate the role of the PmrAB regulatory pathway in laboratory-selected mutants...

Topics

Acinetobacter Infections
Acinetobacter baumannii
Anti-Bacterial Agents
Bacterial Proteins
Base Sequence
Colistin
Drug Resistance, Bacterial
Humans
Microbial Sensitivity Tests
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, DNA

Transcription Factors

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Open in PubMed Open full text

Identifiers

PMID: 29914966
DOI: 10.1128/AAC.00788-18
PMCID: PMC6125516

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